Mir Nasir Khan Talpur of Hyderabad was among the most active Sindhi administrators after the decline of the Mughal Empire he made Hyderabad the center of culture and defense in Sindh and he constructed two great forts in the city known as the Pakka Qilla (Brick Fort) and the Kacha Qilla (Mud Fort) and he also built the Maula Ali Qadam Gah (The footsteps of Ali), a Shea shrine at the center of the city. He was a strong follower of the Sufi tradition. He donated a lot of his personal wealth to the Tomb of Shah Abdul Latif Bhittai at Bhit Shah. He and his 30,000 Sindhi forces were defeated by the forces of the British Empire led by Charles Napier at the Battle of Miani.
Mir Nasir Khan Talpur appealed to the last Mughal Emperor Bahadur Shah Zafar for support but the Emperor was unable to provide any assistance.